What is Omicron and what makes it a concern (VoC) variant?
It is a new variant of SARS-CoV-2 that has recently been reported from South Africa on 24th November 2021 called B.1.1.529 or Omicron (based on Greek alphabets like alpha, beta, delta, etc). This variant has shown many mutations, especially more than 30 on the viral spike protein, which is the key target of the immune response.
Given the collection of mutations in Omicron, which earlier individually have been associated with increased infectivity and/or immune evasion, and the sudden rise in the number of positive cases in South Africa, World Health organization has declared Omicron as a Variant of Concern (VOC).
Can the currently used diagnostics methods, detect Omicron?
The most accepted and commonly used method of diagnostic for SARS-CoV-2 Variant is the RT-PCR method. This method detects specific genes in the virus,such as Spike (S), Enveloped (E) and Nucleocapsid (N), etc to confirm the presence of the virus.
However, in the case of Omicron, as the S gene is heavily mutated, some of the primers may lead to results indicating the absence of the S gene (called as S gene drop out). This particular S gene drops out along with the detection of other viral genes could be used as a diagnostic feature of Omicron.
However, for final confirmation of the omicron variant genomic sequencing is required.
How concerned should we be about the new VoC?
WHO declares a variant as a VoC after the assessment when there is an increase in transmissibility or detrimental change in COVID-19 epidemiology; OR increase in virulence or change in clinical disease presentation; OR decrease in effectiveness of public health and social measures or available diagnostics,vaccines, therapeutics. (Source: WHO)
It is important to highlight that Omicron has been declared VoC based on the observed mutations, their predicted features of increased transmission and immune evasion, and preliminary evidence of detrimental change in COVID-19 epidemiology, such as increased reinfection. The definitive evidence for increased remission and immune evasion are awaited.
What precautions should we take?
The precautions and steps to be taken remain the same as before. It is essential to mask yourself properly, take both doses of vaccines (if not yet vaccinated),maintain social distancing and maintain good ventilation to the maximum possible.
Will there be a third wave?
Omicron cases are increasingly being reported from countries outside of South Africa and given its characteristics, it is likely to spread to more countries including India. However, the scale and magnitude of rising in cases and most importantly the severity of disease that will be caused is still not clear. Further, given the fast pace of vaccination in India and high exposure to delta variants as evidenced by high seropositivity, the severity of the disease is anticipated to be below low. However, scientific evidence is still evolving.
Will the existing vaccines work against Omicron?
While there is no evidence to suggest that existing vaccines do not work on Omicron, some of the mutations reported on the Spike gene may decrease the efficacy of existing vaccines. However, vaccine protection is also by antibodies as well as by cellular immunity, which is expected to be relatively better preserved. Hence vaccines are expected to still offer protection against severe disease and, vaccination with the available vaccines is crucial. If eligible, but not vaccinated, one should get vaccinated.
How is India responding?
Indian government is monitoring the situation closely and is issuing suitable guidelines from time to time. Meanwhile, the scientific and medical community is geared up for developing and deploying diagnostics, carrying out genomic surveillance, generating evidence about viral and epidemiologic characteristics, and development of therapeutics.
Why do variants occur?
Variants are a normal part of evolution and as long as the virus can infect, replicate and transmit, they will continue to evolve. Further, not all variants are dangerous, and most often than not, we don’t notice them. Only when they are more infectious or can reinfect people, etc., they gain prominence. The most important step to avoid the generation of variants is to reduce the number of infections.
Source:
WHO and MoHFW, GoI